منابع مشابه
Controversies in HIV cure research
BACKGROUND Antiretroviral therapy significantly reduces HIV viral burden and prolongs life, but does not cure HIV infection. The major scientific barrier to a cure is thought to be the persistence of the virus in cellular and/or anatomical reservoirs. DISCUSSION Most efforts to date, including pharmaco, immuno or gene therapy, have failed to cure patients, with the notable exception of a stem...
متن کاملHIV cure research: a formidable challenge
The ultimate goal of HIV cure research is to allow HIV-infected individuals to be free of disease in the absence of antiretroviral therapy. We discuss current directions and future opportunities aimed at achieving sustained virological remission, and possibly eradication. A multidisciplinary approach to HIV cure research will be important, and ethical, social and behavioural research should be ...
متن کاملHIV cure research: expanding the ethical considerations.
Mounting evidence is fueling excitement over the possibility of curing HIV-infection. Two “Boston patients” who underwent bone marrow transplantation1 and a “Mississippi baby” who was given aggressive antiretroviral therapy (ART)2 soon after birth seem to be free of HIV-infection. These accounts build upon reports of the “Berlin patient” who lacks evidence of HIV-infection following transplanta...
متن کاملNonhuman Primate Models for HIV Cure Research
1 Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 2 Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 3 Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 4 Department...
متن کاملAnimal models in HIV cure research
Current HIV antiretroviral therapy (ART) successfully inhibits viral replication in the majority of HIV-infected individuals. However, ART is not curative and lifelong adherence is required. Despite the undisputed benefit of ART, long-lived latently infected cells that carry HIV-integrated DNA remain. Hence, upon ART interruption, HIV-infected subjects experience viral rebound. Interestingly, s...
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ژورنال
عنوان ژورنال: Annals of Internal Medicine
سال: 2013
ISSN: 0003-4819
DOI: 10.7326/0003-4819-159-7-201310010-00694